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北京天助畅运医疗技术股份有限公司(英译中)
Abstract
Background It is an undisputable fact that meshes have
become standard for repair of abdominal wall hernias.
Whereas in the late eighties there were only a couple of
diVerent devices available, today we have to choose among
some hundreds, with lots of minor and major variations in
polymer and structure. As most of the minor variations may
not lead to signiWcant change in clinical outcome and may
be regarded as less relevant, we should focus on major
diVerences. Eventually, this is used to structure the world of
mesh by forming groups of textile devices with distinct biological
response. Many experimental and some clinical
studies have underlined the outstanding importance of
porosity, which fortunately, in contrast to other biomechanical
quanlities, is widely unaVected by the anisotropy of
meshes.
Methods In accordance with the major manufacturers of
meshes, a classiWcation of meshes was derived from a huge
pool of textile data based brieXy on the following: (1) large
pores, (2) small pores, (3) additional features, (4) no pores,
(5) 3D structure and (6) biological origin. At 1,000
explanted meshes the value of this classiWcation was evaluated
by group-speciWc assessment of inXammatory and
connective tissue reaction.                                                摘要
背景 毫无疑问,网片已成为修复腹壁疝的标准。八十年代末,可供选择的网片极其有限;而如今,数百种网片可供自由选择,其聚合物和结构方面存在许多或大或小的差异。由于大多数细微差异不会导致临床结局产生显著变化,从而显得无足轻重。因此,我们应将重点放在较大差异上。最终,通过对不同生物反应的织物网片进行分类来构建网片王国。许多实验和部分临床研究强调了孔隙率的显著重要性;幸运的是,相对于其他生物力学特性,孔隙率不受网片各向异性的影响。
方法:主要生产商通过海量织物数据汇总对网片进行分类,依据如下(1)大孔隙;(2)小孔隙;(3)附加功能;(4)无孔;(5)3D结构和(6)生物来源。在1000张移植网片中,通过炎性和结缔组织反应的种群特异性评估对分类价值进行评价

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北京博富瑞基因诊断技术有限公司(英译中)
Sensitization against donor HLA antigens by producing
donor-specific antibodies (DSAs) increases the risk for
hyperacute, acute and chronic rejection, and poor survival
of kidney allografts. Tremendous amounts of clinical and
experimental data indicate that DSAs have pathogenic roles
in allograft rejection, not just an epiphenomenon to
rejection process. Therefore, pretransplantation DSA testing
of recipient sera is now widely applied to guide donor
selection programs, risk assessment of antibody-mediated
rejection (ABMR) and desensitization therapies. International
consensus guidelines also recommend posttransplantation
DSA monitoring with a varied frequency
dependent on pretransplant sensitization risk assessment
and clinical circumstances after transplantation (1). While
serum DSA is associated with ABMR pathology and worse
graft outcomes in patient cohorts, diagnostic and predictive
value of circulating DSA per se in an individual patient is
limited. This is because not all DSAs induce graft injury:
approximately 20–40% of kidney transplant patients with
preformed or de novo serum DSA do not have simultaneous
clinical or subclinical rejection (2,3). With the
introduction of sensitive solid-phase assays, serum DSA
detection is significantly improved but this technical
advancement also led to uncertainty with respect to
interpretation and clinical decision making.供体特异性抗体 (DSA) 的产生能够对抗供体人类白细胞抗原的致敏作用,但也会增加超急性、急性和慢性排斥反应的风险,导致肾移植存活率变差。大量的临床和实验数据表明,供体特异性抗体在同种异体移植物排斥反应中具有致病作用,而不只是排斥反应过程中的偶发症状。因此,移植手术前对受体血清进行供体特异性抗体测试现在已被广泛地应用于指导供体选择方案以及抗体介导排斥反应(ABMR)和脱敏疗法的风险评估中。国际共识指南还建议,根据移植前致敏风险评估和移植后的临床情况,进行不同频率的移植术后供体特异性抗体监测(1)。虽然血清供体特异性抗体与患者的抗体介导排斥反应病理学有关,并可能在患者中导致更糟的结果,但个别患者的循环供体特异性抗体本身的预测值是有限的。 这是因为,不是所有的供体特异性抗体都会导致移植损伤:约20% - 40%的肾移植患者,其预制血清供体特异性抗体或新的血清供体特异性抗体不同时具有临床或亚临床排斥反应(2,3)。随着灵敏的固相分析法的引入,血清供体特异性抗体检测得到了显著提高,但这种技术进步也导致了关于解释和临床决策的不确定性。

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《世界针灸杂志》有限公司(中译英)
临床研究
Clinical Research
不同波型电针治疗肥胖症伴内分泌代谢异常的疗效比较*
Comparison of efficacy of treating obese patients with endocrine-metabolic abnormity with electro-acupuncture of different types of wave modes *
[摘 要] 目的:对比疏密波、连续波电针结合雷火灸治疗不同证型肥胖症伴血脂、血清瘦素异常的疗效,为选择不同电针波型治疗不同证型肥胖症提供临床依据。方法:60例血脂、血清瘦素异常的肥胖症患者按就诊先后顺序,采用随机数字表法分为疏密波组和连续波组,每组30例。按中医辨证分为胃肠腑热型、脾胃虚弱型和脾肾阳虚型,分别给予电针天枢、大横、足三里、上巨虚、丰隆、阴陵泉、曲池、支沟、合谷,并给予雷火灸治疗。疏密波组电针频率为2 Hz/100 Hz, 连续波组电针频率为2 Hz,2组均每天治疗1次,每周6次,共治疗4周,然后随访3个月。比较两组治疗前后和随访时的体质量、体脂百分率;比较两组疗效,并对疏密波组不同证型患者的疗效进行统计。采用全自动生化分析仪检测两组治疗前后血脂水平,用流式细胞分析系统检测两组治疗前后血清瘦素含量. 结果:治疗4周后两种电针波型均能有效降低患者的血脂、血清瘦素水平及体质量、体脂百分率;随访3个月,两组患者肥胖指标继续下降(P<0.01或P<0.05),且疏密波组的改善程度均优于连续波组(P<0.05或P<0.01)。疏密波组疗效明显优于连续波组(P<0.01)。疏密波组不同证型的疗效以脾胃虚弱型最佳。 结论: 疏密波电针结合雷火灸治疗血脂、血清瘦素异常的肥胖症,近期和远期效果均明显优于连续波电针,其中脾胃虚弱型的疗效优于脾肾阳虚型和胃肠腑热型。
[Abstract] Objective: To compare the efficacy of treating obese patients with accompanying abnormity of lipids and serum leptin with dilatational wave or continuous wave electro-acupuncture combined with thunder-fire moxibustion in order to provide a clinical basis for selecting wave types of electro-acupuncture for different patterns of obesity. Methods:  60 obese patients with abnormal lipids and serum leptin were randomly divided into the dilatational wave group and the continuous wave group via random number table, with 30 cases in each group. They were divided by TCM differentiation into three types: stomach-intestine excessive heat, weakness of the spleen and the stomach and spleen-kidney yang deficiency, treated by electro-acupuncture on Tiān shū (天枢 ST 25), Dà héng (大横 SP 15), Zú sān lĭ (足三里 ST 36),  Shàng jù xū (上巨虚 ST 37), Fēng long (丰隆 ST 40), Yīn líng quán (阴陵泉 SP 9), Qū chí (曲池 LI 11), Zhī gōu (支沟 TE 6) and Hé gŭ (合谷 LI 4) along with thunder-fire moxibustion. The frequency of electro-acupuncture in the dilatational wave group and the continuous wave group was 2 Hz/100 Hz and 2 Hz, respectively. Patients in the two groups were treated once a day, six times a week. The treatment lasted for 4 weeks with 3-month follow-up. Body mass and body fat percentage before and after the treatment, as well as during the follow-up, were compared.The effectiveness rates in the two groups were compared, and the efficacy statistics of patients with different TCM patterns in the dilatational wave group were also analyzed. Lipid levels of the two groups before and after the treatment were measured with a automatic biochemical analyzer, and serum leptin levels were detected with flow cytometry system. Results: 4 weeks following the treatment, electro-acupuncture for thetwo types of waves was shown to  effectively reduce patients’ blood lipids, serum leptin levels, body mass and body fat percentage; three months’ follow-up witnessed continuous decline of obesity indicators (P <0.01 or P <0.05), and patients in the dilatational wave group improved more significantly than those in continuous wave group (P<0.05 or P<0.01). The efficacy in the dilatational wave group was superior to that in the continuous wave group (P <0.01). The best efficacy could be found among patients with weakness of the spleen and the stomach in the dilatational wave group. Conclusion: Efficacy of treating obese patients with abnormity of lipids and serum leptin with electro-acupuncture combined with thunder-fire moxibustion in the dilatational wave group was significantly better than the  continuous wave group, and efficacy for obese patients with weakness of the spleen and the stomach was superior to that of those with stomach-intestine excessive heat and spleen-kidney yang deficiency.

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